'mydibreakfast, ~lunch & ~dinner for mydilovers'


~@~


"Round~the~Clock
myDi~Metabolism"


The behavior
of most mydi~organisms
is organized around a
24~hour cycle.

One
of the key molecular regulators
of this circadian rhythmicity
is a transcription factor
called CLOCK.

Mice
carrying a mutation of the Clock gene
show profound disturbances
in circadian behavior.

Experiments
during the last years
now show that these Clock mutant mice also overeat,
become overweight, and develop features of metabolic syndrome, included elevated
serum levels of glucose
and lipids.

The metabolic
disturbances were accompanied
by alterations in the expression of neuropeptides
implicated in appetite control
and energy
balance.



~@~

~@~


"Out of myDi~Africa Revisited"


The mydi~route of human colonization of Asia after dispersing out of Africa
about 60,000 years ago has remained unresloved.

DNA sequence analysis of existing populations can provide phylogenies that can be mapped
onto geographic distribution.

We tested alternative mydi~models for the settlement of Eurasia by modern humans
using complete mitochondrial (mt) DNA genomes (which provide the hihghest possible resolution
of the maternal genealogical tree) by studying the "missing link" of Southeast Asian
aboriginal populations.

Only ONE model ~ a single, rapid dispersal along the coast from East Africa to India and thence to
Southeast Asia and Australasia ~ can explain the phylogenetic patterns observed.

Moreover, all subsequent mydi~peopling of Europe and Asia cab be explained by this initial dispersal event: we have successfully identified M31 & M32 mtDNA types among indigenous Andaman islanders
which show that these populations became genetucally isolated about 50,000 to 70,000 years ago,
apparently AFTER their initial migration from Africa.


~@~

~@~


"The Maturing
myDi~Repertoire of
Canary Songs"


A canary's song is made up of units of sound
organized with syntax and phrasing.

We have now distinguished some of the forces that shape the adult bird's song.

When young canaries were isolated from other birds' songs,
they showed remarkable ability to mimic synthetic songs that were far from the normal canary song.

However,
as these birds matured, their songs became more typical of normal adult canaries,
despite having never heard such songs.

Thus,
with maturity in the canary comes a loss of vocal flexibility,
and increasing dominance of an innate program
of song structure.

~@~

~@~

'Bon Appetit
&
May the myDi~Force
be With You
Too!'

~@~
~@~

Take a Nap
every now & then;
take Care of each other because we are all ONE big related family,
and Know that, even though we might sing all kinds of Very Different Songs,
we CAN share One Language & One Frame of myDi~Mind
within which almost Everything we really Want
IS
'possible
within reason'?

~@~
~@~
11 apr 2006 - bewerkt op 15 mei 2008 - meld ongepast verhaal
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Profielfoto van Asih
Asih, man, 81 jaar
   
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